Revolutionize Nanoparticle Formulation

Systems for lipid nanoparticle (LNP) production

IJM NanoScaler

This benchtop IJM NanoScaler system is designed for lipid nanoparticle R&D – allowing scientists to screen for the optimal process parameters.

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IJM NanoScaler PRO

The innovative IJM NanoScaler PRO system is designed for automated lab-scale formulation of lipid nanoparticles.

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IJM SingleCore NanoProducer

IJM SingleCore NanoProducer (Impingement Jets Mixing technology) for the high-flow production of nanoparticles (LNP, microemulsions etc.).

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IJM DuoCore NanoProducer

IJM DuoCore NanoProducer (Impingement Jets Mixing technology) for the production of nanoparticles.

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Customized NanoProducer

Production-scale IJM system (Impingement Jets Mixing technology) for the production of API-loaded lipid nanoparticles. 

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Impingement Jets Mixing Systems – from R&D to manufacturing

Use our revolutionary Impingement Jets Mixing Systems to explore the emerging field of nanoparticle production. Consider the ability to fully control particle size, distribution, and morphology to achieve the flawless homogeneity that differentiates your products.

Plus, our solution increases efficiency, not just precision. Say goodbye to inefficient processes and hello to simplified manufacturing that saves time and money while increasing productivity.


No matter how big your goals are, our mixing systems are the answer. Move from research to extensive industrial applications without losing focus on performance or quality. Take the lead in innovation with the assurance of proven knowledge. Designed by industry pioneers and backed by years of research, our IJM systems give you an unbeatable competitive advantage.


But in addition to a product, we also provide unwavering support. Our dedicated team is here to partner with you to ensure your operations are streamlined and obstacles are quickly overcome.

Modularity – Seamlessly Incorporating Dual Valve Configuration

Scaleability –From R&D Excellence to Seamless Production

Durability –
No wear parts, no plastic waste, no cartridges

Cleanability –
Experience the Ease of Clean-In-Place (CIP)

What the Expert says

I am delighted that we have been able to successfully deliver all our systems for vaccine production on time. It makes our team proud that we are helping to combat COVID-19 in this way.


Lilit Avagyan, Team Leader Customized Solutions


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Conformity –GMP, GAMP 5, CFR21 Part 11 Compliance at the Core

Usability –Unified & User-Friendly Systems and Software

Singularity –Introducing IJM Technology by KNAUER

Quality –Unmatched Engineering,
Stainless Steel Construction 


Logo eTheRNA

What the customer says

Having already a robust LNP production process in place, we were looking out for alternative techniques to support our scale-up activities. The Impingement Jets Mixing (IJM) equipment provided by Knauer was the right fit for us! Even from early runs we were able to produce LNPs of high quality with a high encapsulation efficiency and low PDI values. We will further build on this and expand our knowledge into GMP production to further support our projects and partners by delivering high quality LNP production.


Iris Bombeke, Research Associate Drug Product Development eTheRNA, Ghent, Belgium

Impingement Jets Mixing Technology (IJM)
Impingement Jets Mixing Technology (IJM) enables the formulation and production of high-quality lipid nanoparticles carrying API (e.g. for mRNA vaccines). The encapsulation process of active pharmaceutical ingredients with lipids is based on Impingement Jets Mixing Technology, where two streams collide at high velocity in a jet mixing chamber.

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