Adapt the sample injection mode to your preparative task

Manual or automated injection: Use a valve or a valve with feed pump for feed injection. Sample injection can be easily automated using AS 6.1L autosampler, which can inject up to 10 ml per injection, or with the LH 2.1 Liquid Handler.
 

Select your preferred injection option:

• Manual or automated injection valve with sample loop or Variloop up to 40 ml sample
• Sample pump for large sample volumes
• Autosampler or Liquid Handler for increased througput

The KNAUER VariLoops are the perfect solution for the injection of medium up to high sample volumes (up to 40 ml). The sample loop can be emptied completely or partially as well as filled completely or partially. This allows you to work very flexible and easily switch between different sample sizes while keeping constant and reproducible injection volumes for every sample size.

Column Switching 

Switching valves are ideal for screening and scaleup. They can be easily integrated into your system at pressures up to 400 bar and maximum flow rates  of 300 ml/min. Up to 16 columns can be selected.

Temperature Control 

Increase performance. Minimize solvent viscosity. When performing preparative LC at temperatures  above 40°C in air-conditioned laboratories e.g. in RNA purification processes, a uniform temperature distribution is essential.

• Eluent and Column Heater
• Column Heating Sleeve
• Column Oven
• Pump Head Heater

Detection options

KNAUER gives you the opportunity to analyze nearly every compound due to a large portfolio of HPLC detectors. For the achievement of your analysis goals and for matching your separation scale, our detectors are flexible in the setup, including flow cells and fiber optics. Our product line of UV/VIS detectors ranges from single variable wavelength to 8-channel diode array detectors with 3D scan capability.

Additional Options:

• AZURA® RID 2.1L HighFlow
• Light Scattering Detector 
• Conductivity Monitor
• Mass spectrometry

Fiber optics technology

More flexibility and safe operation Fiber optic cables offer the possibility to separate the flow cell from the detector. This enables demanding applications such as measuring directly after a heated LC column or in hazardous environments, allowing safe operation of the instrument while maintaining performance.

Collect large quantities or large numbers of fractions

KNAUER offers different valves for fraction collection and variations of trusted fraction collectors. Whether you are doing research and development or production, there is an appropriate solution.

• KNAUER Fraction Collector FC6.1: Entry level fractionation option 
• LABOCOL Vario 4000 / Plus: Versatile fractionation at higher flow rates
• Liquid Handler LH2.1: Automating preparative separations with highest flexibility and throughput
• Fractionation valves: Large volumes

Software Solutions

KNAUER offers various chromatography software solutions to meet your requirements. Our software packages are designed to deal with different levels of complexity and laboratory size. The well-known software solutions work with KNAUER instruments, but can be combined with a variety of other instruments. Ask for details.  All of these solutions are also available with preparative functionality to enable chromatography purification tasks. You will find this option implemented so consistently only at KNAUER.

• PurityChrom® 6
• Mobile Control (Chrom) 
• ClarityChrom® CDS
• OpenLab
• Chromeleon™